Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But rapid evolution should come at a cost. Most mutations…
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New understanding of B cell mutation strategies could have implications for vaccines
A vaccine’s ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies. But each round of this process is a roll…
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Classifying childhood brain cancers by immune response may improve diagnostics and treatments
Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.
Today in Science Translational Medicine,…
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Are you a night owl? You’re more at risk of depression. Here’s why
The early bird catches the worm, while the night owl is more at risk of developing depression. That’s according to a new study that suggests people who prefer waking up and staying up late are more likely to experience depressive symptoms, compared to early risers
A study by the University of…
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Israel launches ground operation to reoccupy corridor which splits Gaza in half
The Israeli military had previously withdrawn from the Netzarim Corridor, which it established, following a temporary ceasefire agreement with Hamas.
Israel has launched what it is calling a “limited ground operation” to retake part of the key Netzarim Corridor, the…
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Video. Fallas 2025: Valencia’s fireworks defy the rain
Valencia’s iconic firework spectacle, “La Nit del Foc” (the night of fire), dazzled crowds despite heavy rain, filling the night sky with colour, light, and sound. The Hermanos Caballer pyrotechnics team launched 1,405 kilos of fireworks in a breathtaking 20-minute display from the Jardines…
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The ‘Big Bet’ Changing How America Eats
The Rockefeller Foundation is betting big that Food Is Medicine can improve health, lower costs, and … More
Herman Johnson never imagined that something as simple as fruits and vegetables could change his life. A retired Army veteran from Houston, Texas, Johnson had…
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Trump Administration Sends Mixed Messages On Vaccines
In this week’s edition of InnovationRx, we look at the policy uncertainty around vaccines, sex differences in GLP-1 drug side effects, the challenges of using AI to predict epidemics and more. To get it in your inbox, subscribe here.
PA Images via Getty Images
One of the major concerns…
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Frontline report: Pokrovsk commander applies Kherson lessons to push back Russian forces
Day 1119
On 18 March, there are a lot of interesting updates from the Pokrovsk direction.
General Mykhailo Drapaty, after stabilizing the situation on the front, managed to set the stage for decisive counterattacks that turned the tide of battle in the most critical sector of the front line,…
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After 9 Months in Space, Stranded NASA Astronauts Return Home
Suni Williams and Butch Wilmore, the US astronauts stranded for nine months on the International Space Station, finally made it home on Tuesday, March 18. They returned to Earth with the two members of the SpaceX Crew-9 mission—NASA’s Nick Hague and Russian cosmonaut Aleksandr Gorbunov of…
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