Existing research indicates that the accuracy of a Parkinson’s disease diagnosis hovers between 55% and 78% in the first five years of assessment. That’s partly because Parkinson’s sibling movement disorders share similarities, sometimes making a definitive diagnosis initially difficult.
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Rethinking how we study the impact of heat on heart health
Scientists have been testing how heat affects our hearts for years. But here’s the thing: the most commonly used method might not provide much insight into what happens to the heart during heat waves.
A new study led by the University of Ottawa, Human and Environmental Physiology Research Unit…
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Pregnancy irreversibly remodels the mouse intestine
Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare for a second.
The organs of many female animals are remodelled by reproduction, but the…
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New study challenges assumptions about SEP-1 bundle compliance and sepsis outcomes
A new study led by the Center for Sepsis Epidemiology and Prevention Studies (SEPSIS) at the Harvard Pilgrim Health Care Institute raises critical questions about the effectiveness of the Centers for Medicare and Medicaid Services’ (CMS) sepsis quality measure, known as the Severe Sepsis/Septic…
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Earliest stages and possible new cause of stomach cancer revealed
For the first time, scientists have systematically analysed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer. The team also uncovered hints of a potential new cause of stomach cancer that needs further research.
Researchers at the…
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Machine learning aids in detection of ‘brain tsunamis’
A University of Cincinnati study found machine learning models can aid in the automation and detection of abnormal brain activity sometimes referred to as a “brain tsunami.”
UC’s Jed Hartings, PhD, is corresponding author of the study published March 12 in the journal Scientific Reports…
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Classifying childhood brain cancers by immune response may improve diagnostics and treatments
Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.
Today in Science Translational Medicine,…
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New understanding of B cell mutation strategies could have implications for vaccines
A vaccine’s ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies. But each round of this process is a roll…
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New mechanism behind adaptive immunity revealed: It could impact how we design vaccines
Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But rapid evolution should come at a cost. Most mutations…
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Why are night owls at greater risk of depression?
Mindfulness, total sleep quality, and alcohol consumption may help explain why people who stay up late have a greater risk of depression, according to a new study publishing March 19, 2025, in the open-access journal PLOS One by Simon Evans of University of Surrey, UK, and colleagues.
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